Observational Studies

Observational studies take place on the Mass General Hospital (MGH) campus and the Brigham and Women’s Hospital (BWH) Campus.

Alzheimer's Clinical Trial Unit (ACTRU) - MGH

To be populated

Center for Alzheimer Research and Treatment (CART) - BWH

CART, in collaboration with Brigham and Women’s Hospital and Harvard Medical School, offers numerous innovative prevention and  treatment trials. Their mission is two-fold:

1) to improve the early diagnosis of Alzheimer’s disease (AD) employing more sensitive clinical evaluations, biological markers, and neuroimaging; and

2) to assess promising new treatments for AD.

They conduct both observational studies, in which participants undergo cognitive and brain imaging tests in order to understand brain aging and improve early diagnosis of AD; and therapeutic clinical trials, in which participants receive an experimental drug or a placebo to test new treatments for AD.

For more information, connect with their recruitment
specialist Allyson Pulsoni: apulsoni@bwh.harvard.edu

Current CART Clinical Trials:

AHEAD (A3/A45) – A preventative trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of the drug BAN2401 on individuals with both intermediate and elevated levels of amyloid. For more information contact Allyson Pulsoni: 617-525-3167, apulsoni@bwh.harvard.edu

Clarity – A phase III clinical trial testing the drug BAN2401 on individuals with Mild Cognitive Impairment or Mild Alzheimer’s Disease dementia through bi-weekly infusions. For more information contact Allyson Pulsoni: 617-525-3167, apulsoni@bwh.harvard.edu

Current CART Observational Studies

Frontotemporal Disorders Unit- (FTD Unit) - MGH

The FTD Unit provides diagnosis and treatment for frontotemporal dementia and related disorders, including Primary Progressive Aphasia, Semantic Dementia, Corticobasal Degeneration Syndrome, and Progressive Supranuclear Palsy. They work with patients and families with young-onset and atypical forms of Alzheimer’s disease, as well as collaborate with the Frontal Temporal Lobe Society to offer unique services for caregivers.

The FTD Unit closely collaborates with other centers including Brigham & Women’s Hospital, Beth Israel Hospital, Jamaica Plain VA Aphasia Research Center, the Association for FTD and the Alzheimer’s Association.

Current FTD Clinical Trials:

The TMS Study – The use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logopenic or non-fluent variant of primary progressive aphasia. For more information contact, Courtney Sullivan: csullivan65@Partners.org

Current FTD Observational Studies

Affiliate Site Clinical Trials