5-Year Major Projects (1984 - Present)

Genetic Analysis of Alzheimer's Disease

Project Year(s): 
1997 to 2002
Principal Investigator(s): 

Rudolph E. Tanzi, PhD

Most Recent/Current Position(s): 

Director, Genetics & Aging Research Unit, Mass Gen Institute for Neurodegenerative Disease & Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Harvard Medical School

Mechanism and Inhibition of Native Amyloid-Beta Aggregation in Cells

Project Year(s): 
1997 to 2002
Principal Investigator(s): 

Dennis J. Selkoe, MD

Most Recent/Current Position(s): 

Co-Director, Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital & Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School

Functional MRI in Aging and Alzheimer's Disease

Project Year(s): 
1993 to 1995
Principal Investigator(s): 

Suzanne H. Corkin, PhD

Most Recent/Current Position(s): 

Professor Emerita of Behavioral Neuroscience, Massachusetts Institute of Technology & Lecturer on Radiology, Harvard Medical School

Receptor-Coupled ADD Processing

Project Year(s): 
1993 to 1997
Principal Investigator(s): 

John H. Growdon, MD

Most Recent/Current Position(s): 

Founding Director, Massachusetts ADRC & Professor of Neurology, Harvard Medical School

Regulation of Amyloid-Beta Production in Health and in Alzheimer's Disease

Project Year(s): 
1993 to 1997
Principal Investigator(s): 

Dennis J. Selkoe, MD

Most Recent/Current Position(s): 

Co-Director, Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital & Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School

Cholinesterases in Alzheimer's Disease

Project Year(s): 
1988 to 1993
Principal Investigator(s): 

M. Marsel Mesulam, MD

Most Recent/Current Position(s): 

Director, Northwestern University Alzheimer's Disease Center & Ruth and Evelyn Dunbar Professor of Neurology and Psychiatry, Northwestern University Feinberg School of Medicine

Neuronal Protease Expression

Project Year(s): 
1988 to 1993
Principal Investigator(s): 

Ralph A. Nixon, MD, PhD

Most Recent/Current Position(s): 

Director, The Center for Dementia Research, Nathan S. Kline Center for Psychiatric Research & Executive Director, Pearl Barlow Center for Memory Evaluation and Treatment & Professor of Psychiatry and Cell Biology, New York University School of Medicine

Histochemistry of the Cystoskeleton in Alzheimer's Disease

Project Year(s): 
1988 to 1990
Principal Investigator(s): 

Neil W. Kowall, MD

Most Recent/Current Position(s): 

Director, New England Geriatric Research Education and Clinical Center & Chief of Neurology, Veterans Affairs Boston Healthcare System & Director, Boston University Alzheimer's Disease Center & Professor of Neurology and Pathology, Boston University School of Medicine

Pathogenesis of Alzheimer's Disease

Project Year(s): 
1988 to 1990
Principal Investigator(s): 

James E. Hamos, PhD

Most Recent/Current Position(s): 

Program Director, Math and Science Partnership Program, National Science Foundation

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